"We should keep our eyes wide open to what side effects and adverse events might occur, and still keep in mind that this is a new product," Offit says. You can still be confident going in, he says - just don't be 100% sure what to expect. enlarged lymph nodes (more frequently observed after the booster dose) feeling unwell arm pain insomnia injection site itching allergic reactions such as. The BA.1 trials only tested a few hundred people, which is a relatively small sample size compared to the thousands of Americans set to receive the new BA.5 doses, Offit notes. Its updated booster has 25 micrograms targeting the original strain, and 25 targeting the omicron subvariants. In addition, side effects can be reported to Pfizer Inc. About the Pfizer and University of Texas Medical Branch (UTMB) Study. Moderna's monovalent shot contains 50 micrograms of mRNA per dose targeting the original strain. Data on the persistence of neutralizing titers over time after a booster dose of BNT162b2 against the Omicron variant will be collected. The updated booster shots c ontain the same number of micrograms, with 15 targeting the original strain and the other 15 targeting BA.4 and BA.5. The new shots have the same dosage amounts as the original vaccines, which further suggests that their safety profiles could be similar, Offit says.Ī single dose of Pfizer's monovalent vaccine contains 30 micrograms of mRNA targeting the original Covid strain. The same concept held true during the last round of booster shots. You're only eligible for the new boosters if you've completed a primary vaccination series, meaning most people will have already received at least two doses ahead of time. Severe side effects are "generally" most common after receiving a second dose of a vaccine, not after receiving a third or fourth dose, says Offit. Moderna's trial found that nearly 59% of participants experienced fatigue, but only about 4% experienced that at a Grade 3 level, which is defined as significant fatigue that prevents daily activity. Roughly 26% of participants experienced a mild or moderate headache, while only 0.3% experienced a severe one. Pfizer's trial found that about 52% of participants that received the BA.1 shot experienced mild pain at the injection site, 8% experienced moderate pain and only 0.3% experienced severe pain. But notably, in those clinical trials, the severity of the side effects was very mild. That's a familiar list: It's the same group of side effects that came with the original formulations. Redness and swelling at the injection site.In both clinical trials, the most commonly reported side effects within seven days of receiving the shot were: In Pfizer and Moderna's clinical trials for the BA.1 shots, participants who were already fully vaccinated with a booster shot received an updated booster dose. Side effect data isn't available yet because the new boosters were approved by the FDA and Centers for Disease Control and Prevention before fully completing their clinical trials. Individuals 5 to 11 can still get the original boosters." The Expected Side Effects So, anybody over the age of 12 who's looking for a booster, this is the one that they're going to get. "We really want folks to get these updated. Allison Arwady, Chicago's Department of Public Health commissioner, said earlier. "With this new authorization, the monovalent - meaning the old version - are not authorized anymore as booster doses," Dr. doi:10.1001/, performances commemorate Juneteenth this weekend in Chicago, suburbs Delayed localized hypersensitivity reactions to the Moderna COVID-19 vaccine: a case series. Johnston MS, Galan A, Watsky KL, Little AJ. Reactogenicity following receipt of MRNA-based COVID-19 vaccines. In clinical trials, the most commonly reported side effects for the latest COVID-19 boosters included sore arms, fatigue, and headache, according to data from Moderna and Pfizer trials. The second dose of a COVID-19 vaccine: Side effects, why they happen, and how to treat them.Ĭhapin-Bardales J, Gee J, Myers T. 5 exercises to reduce arm soreness after the COVID-19 vaccination. Sheltering Arms Physical Rehabilitation Center. Use of COVID-19 vaccines after reports of adverse events among adult recipients of Janssen (Johnson & Johnson) and mRNA COVID-19 vaccines (Pfizer-BioNTech and Moderna): Update from the Advisory Committee on Immunization Practices - United States, July 2021. Rosenblum HG, Hadler SC, Moulia D, et al. Local reactions, systemic reactions, adverse events, and serious adverse events: Pfizer-BioNTech COVID-19 vaccine. Interim considerations: preparing for the potential management of anaphylaxis after COVID-19 vaccination.Ĭenters for Disease Control and Prevention. Possible side effects after getting a COVID-19 vaccine.Ĭenters for Disease Control and Prevention. doi:10.1001/jamadermatol.2021.1214Ĭenters for Disease Control and Prevention. Delayed localized hypersensitivity reactions to the Moderna COVID-19 vaccine: A case series.
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